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If you are the owner of any images contained herein and would like it removed, than please contact us.DESCRIPTION: This Phase I SBIR proposal seeks to develop an innovative and effective vaccine to prevent Mycobacterium avium-intracellulare (MAI) infection in people with AIDS. MAI is a significant opportunistic pathogen which is prevalent in the majority of AIDS patients in the US. People with AIDS are severely immunocompromised and may succumb to disseminated MAI disease. Vaccine approaches that induce a protective immune response are an important priority in the effort to treat and prevent AIDS-related opportunistic infections. Previous studies using a purified protein derivative (PPD) of MAI to immunize mice have shown that it induces strong specific T cell proliferative responses and a significant protective response. A murine monoclonal antibody (CIP-20) to MAI also protects mice against MAI challenge. Therefore, both MAI-specific CD4+ and CD8+ T cell responses and protective antibody may be induced by MAI-PPD, the major antigen in MAI-containing PPD. In this study, a bifunctional fusion protein composed of the major antigenic portion of MAI-PPD and a cell membrane antigen 0b46394aab