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Category:Portuguese numismatics[Pharmacokinetic study of azlocillin and its combination with polymyxin B in the treatment of septic shock].

Pharmacokinetic studies of azlocillin and its combination with polymyxin B in the treatment of septic shock were carried out in 20 patients. Before treatment a 5 ml blood sample was drawn from the antecubital vein. After administration of azlocillin, blood samples were collected at intervals of 0, 15, 30, 45, 60, 120, 240, and 480 minutes and at intervals of 2, 4, 6, 8, 12, and 24 hours. When azlocillin was administered alone, levels of azlocillin in serum were as low as 1.63 micrograms/ml at 1 hour and 0.38 microgram/ml at 3 hours, while, when azlocillin was given in combination with polymyxin B, levels of azlocillin in serum were as high as 2.42 micrograms/ml at 1 hour and 1.45 micrograms/ml at 3 hours. In addition, the area under the level time curve (AUC) of azlocillin given in combination with polymyxin B was approximately 2.7 times higher than that of azlocillin given alone. Because of this increase in AUC, the therapeutic effect of azlocillin given in combination with polymyxin B was considered to be superior to that of azlocillin given alone.Hundreds of mourners gathered at Christ Church Cathedral in London on Tuesday (February 5) to pay their respects to two of the UK’s most prominent media figures – the BBC’s political editor, Laura Kuenssberg, and the Sun’s deputy editor, Michelle Stanistreet.

The funeral of both journalists took place on the same day, 16 hours apart, and included a number of major media figures, including Rupert Murdoch’s former chief executive, George Forsyth, and former and current editors of the Sun.

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